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- Shattered Planet #305640 platinum unknown
- She and the Light Bearer #658590 platinum unknown
- Sheep Love #1520060 platinum unknown
- Shelldiver #3862670 platinum unknown
- ShellShock Live #326460 platinum unsupported
- Shelter #244710 platinum unknown
- Shenmue III #878670 platinum hackable
- SHENZHEN I/O #504210 platinum native
- She Remembered Caterpillars #470780 platinum native
- Sherlock Holmes and The Hound of The Baskervilles #209230 platinum unsupported
- Sherlock Holmes Consulting Detective: The Case of the Mystified Murderess #376790 platinum unsupported
- Sherlock Holmes The Awakened #1949030 platinum hackable
- Sherlock Holmes: The Awakened (2008) #11140 platinum unknown
- Sherlock Holmes: The Mystery of the Mummy #11130 platinum unsupported
- Sherlock Holmes: The Mystery of the Persian Carpet #11180 platinum unsupported
- Sherlock Holmes: The Silver Earring #11150 platinum unsupported
- Sherlock Holmes versus Jack the Ripper #11190 platinum unsupported
- Shift Happens #359840 platinum unknown
- Shiftlings #310810 platinum native
- Shift Quantum - A Cyber Noir Puzzle Platformer #700520 platinum unknown
- Shin chan: Me and the Professor on Summer Vacation The Endless Seven-Day Journey #2061250 platinum unknown
- Shining Resonance Refrain #809890 platinum native
- Shin Megami Tensei V: Vengeance #1875830 platinum hackable
- SHINOBI: Art of Vengeance #2361770 platinum unsupported
- Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island #2178480 platinum unsupported
- Shiren the Wanderer: The Tower of Fortune and the Dice of Fate #1178790 platinum unsupported
- Shmups Skill Test #430290 platinum unknown
- Shogo: Mobile Armor Division #610860 platinum native
- Shogun Showdown #2084000 platinum unknown
- Shoot Many Robots #96400 platinum hackable