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- Serious Sam 3: BFE #41070 gold native
- Serious Sam 4 #257420 gold native
- Serious Sam Classics: Revolution #227780 silver native
- Serious Sam Fusion 2017 (beta) #564310 gold native
- Serious Sam HD: The First Encounter #41000 silver native
- Serious Sam HD: The Second Encounter #41014 silver native
- Serious Sam's Bogus Detour #272620 pending native
- Serious Sam: Siberian Mayhem #1792250 platinum native
- SEUM: Speedrunners from Hell #457210 platinum native
- Seven: Enhanced Edition #471010 gold native
- Severed Steel #1227690 platinum native
- Sex with the Devil #1202690 platinum native
- Shadow Bug #656550 native
- Shadow Empire #1154840 gold native
- Shadow Gambit: The Cursed Crew #1545560 platinum native
- Shadow Harvest: Phantom Ops #92700 pending native
- Shadow Man Remastered #1413870 platinum native
- Shadow of the Tomb Raider: Definitive Edition #750920 protondb gold native
- Shadowrun: Dragonfall - Director's Cut #300550 platinum native
- Shadowrun: Hong Kong - Extended Edition #346940 platinum native
- Shadowrun Returns #234650 platinum native
- Shadows: Awakening #585450 gold native
- Shadows: Heretic Kingdoms #256030 platinum native
- Shadows of Doubt #986130 platinum native
- Shadows Peak #359940 gold native
- Shadow Warrior #233130 platinum native
- Shadow Warrior Classic Redux #225160 gold native
- Shadwen #425210 gold native
- Shady Knight #1155650 platinum native
- Shakedown: Hawaii #598730 platinum native